Dr. Fung basically said that beta cell death is likely related to fatty deposits on the pancreas. So there is a fatty liver/pancreas cycle that requires a significant time duration of fasting. Eventually beta cells continue to produce normal amounts of insulin. T2D is not a death sentence, it just requires motivation from the patients and up-to-date knowledge of the treatment physician.
Years ago, back in like 2011, I worked for pricedoc.com, this was our primary goal as well. Doctors wouldn't talk to us. Legally they're bound to not due to their insurance contracts. The only doctors we gained some traction with were plastic surgery, and dental. Because these doctors tend to deal more with cash patients. We didn't survive long. Maybe 14 months. Then sold our IP to some other startup called greatvets.com and we struggled like crazy to get exposure by vets to want to use our product. Same goal to provide cash prices. Good luck.
Oo that's a good domain name! I think this space is pretty challenging. We actually wanted to work on this before the regulation came out and ran into similar issues - however thanks to the transparency in coverage rule, we have access to their pricing info without having to speak to a single doctor! Although we still need to make relationships with doctors in order to get the business part to work.
We did hear from some dentists that their insurance company forbids them from sharing their rates, which makes it tough to add dentists to our platform.
If you want dentists on your platform, try to find dentist who are "fee for service", that's what the no-insurance shops call themselves.
If you have any other questions about working dentist, feel free to email me and we can setup a call. My wife is a dentist and we've learned a thing or two over the years.
Excessive sweet food causes insulin resistance, which makes your body flood with insulin for even the smallest amount of sugar, it makes you constantly store fat over using it for energy, it's partially why you get food coma from eating a subway sandwich. Soybean oil may play a role in causing mutations in our gene expression making our systems run less ideally. https://www.sciencedaily.com/releases/2020/01/200117080827.h...
CI/CO is ideal circumstances, just like falling from the sky, computing how long it takes to hit the ground is not as simple as it's 9.8ms/s^2*m, you have to build a differential equation that accounts for all the various force factors involved. Our biology are those various force factors playing on the rate of incorporation of the energy and how the system which consumes energy may alter pathways, and this is where we run into permutations of the metabolism that are not accounted for by CI/CO. We know that people with metabolic syndrome and insulin resistance cannot loose weight because their hyper sensitive to any amount of sugar, so insulin causes them to constantly store energy, but some people who eat a lot of calories get a massive energy boost like they almost got some caffeine in their system. Our biology has millions of biological permutations that ideal systems cannot account for.
I'm going to disagree with you. CI/CO is absolute. The issues people get stuck on is twofold:
Calories in is largely correct, however it comes with a few small cavaets. If you eat an excess amount of food (and I mean a LOT, 6000cal+), you probably cannot disgest all of it. For normal sane amounts of calories you're going to digest the vast majority of them. For certain folks, they may have trouble digesting certain types of food. This is going to impact far fewer people than most think, I believe.
The much bigger one is calories out. What you burn can change a lot. Certain bodies adapt their calorie burn quite quickly to calorie reduction. Unconscious effort changes can heavily increase or reduce calorie usage.
There's very little about sugar that inherently makes it "constantly store energy" for certain people. Its calories like anything else, and if you eat tons of it, it's just tons of calories.
The final note is that certain people can have huge swings in water retention depending on food eaten. Salty foods do this for most people. But that isn't true weight gain, and should be largely ignored.
Years of experience is relative to the company, and software type. Companies like Google, production products are likely on a totally different level than almost any other product in existence. So 10yrs at none google company is not equal to Google engineering. What plays into all of this is the complexity of the problems they solve at scale, and level of academic sophistication. Map software, search engines, Google app suite gui products are not simple or easy to build.
Gain of function? You realize that mother nature is far more sophisticated than us humans. She has manufactured many plagues over the eons. we will likely never come up with viruses that have the kind of crazy cascading systemic building block chaos causing destruction in the human body. Radiation doesn't count because we just figured out we could harness it, but we have very little control over that. Viruses make ionic radiation look like child's play as just like ionizing radiation, studying the thing could kill you within days/weeks/months. You have a voodoo science belief that Dr Evil might create the next real zombie, only @9pm on Fox.
It's really funny how media coverage, combined with all the conspiracy-inducing effects of a global pandemic, have made the concept of "gain of function research" into something that is somehow combinable with 23andMe's database.
I haven't been following much of the media coverage of things like this, or the social media rumor mills, but a comment like that makes it clear that public perception is going way off kilter. And that mismatch between public perception and reality is exactly what fuels bad policy in governments.
Your lack of concern for gain-of-function research is not shared by experts in the field. They almost uniformly appreciate that that there is a risk of creating a pandemic that would be unlikely to arise naturally, and they take strong (but, imo, not nearly strong enough) safety steps to prevent it.
Nature generally didn't develop wheels or nukes either, but humans did and use them to great effect.
Not sure which country you live in, but if you can get a speed queen branded washer / dryer, you'll likely never have to replace them. They're repairable.
Agreed that the government at the highest level should pay a huge amount of money. Though I think he should get $10^7 and the rest of the $10^8 should become an endowment for a criminal justice/prison reform organization and he can lead it.
my fiancee, her family. lives in Mecca, Ca, not too far from indio, ca, which is where the Cochella festival is, and they can only get ATT ADSL2, they get 6mbit/1.5mbit and it's a joke. using even tmobile 4g only gets you 10mbit for a few seconds via bursting speeds.
