Not the original commenter, but typically nobody feels anything their first time smoking. Sometimes, people don't even feel it a couple times after that. I'm not sure what the biological reason for that is, but it's been that way for nearly every person that I've talked to.
I've never heard of anyone not being affected by it after a couple times of smoking or eating infused foods.
A lot of people with no smoking experience don't get enough in the lungs the first few times. Actual unresponsiveness to THC is very rare if it exists at all.