I'm an advocate of frameworks, but only for fast prototyping. Nothing beats designing in the browser using Haml (http://haml-lang.com/) and Compass/Sass (http://compass-style.org/) in conjunction with Static Matic (http://staticmatic.rubyforge.org/). Compass has blueprint integrated and using mixins you can avoid having an un-semantic mess in your Haml/Html.
Truth be told though, I use less and less the blueprint features in Compass each day. I find grids amazing for Photoshop (I generate a grid like the one in this thread for every comp) and Keynote/Wireframing/Initial Prototyping (I use a simple broad grid to do wireframes in Keynote), but really don't belong on my markup!
Truth be told though, I use less and less the blueprint features in Compass each day. I find grids amazing for Photoshop (I generate a grid like the one in this thread for every comp) and Keynote/Wireframing/Initial Prototyping (I use a simple broad grid to do wireframes in Keynote), but really don't belong on my markup!