Generally I think the use case is "duplicate the boot volume of my machine onto an attached usb drive" though I think these days not all Macs will boot from an external drive? I have SuperDuper doing scheduled backups like this, along with Backblaze for offsite (but not so bootable) backups.

Ever since a few major macos versions ago, I don't think that is possible anymore.

Maybe if the location can be mounted as a network drive. But I'd say it would be making it do something it is not intended to do. I'd say it is really meant for backing up to external storage or drives on the local network.

There are probably better tools for this.