I guess something like an OS that boots and then only plays the game using a raw memory page for vga and interrupts for keyboard input, not something that is hosted on UEFI.
Or controlling a DAC hat to drive s video, or using lvds. Microcontroller techniques make more sense than trying to use the gpu in a pi, at least it seems that way to me. Is there is enough known about the gpu in any of the versions of the pi to forgo the blob when making a video buffer?