Upon first look at the map, I thought it had to have loaded wrong to not see it starting at what I expected as a port city. From someone that grew up around rivers that can pretty much run dry during the summers, it's amazing to me that a river runs that wide/deep that far inland to a land locked area to be able to accommodate a ship of this size.
I couldn't find the exact port they're starting at, so I guessed a boat ramp just to put a pin somewhere. The only places near Manchester, OH I could find that looked like they had some kind of port facilities were what appeared to be a power plant, although per Wikipedia, the plant has been decommissioned, so it's possible that part of the site was reused for the offloading facility.
The Ohio River is famously an easily navigable river; there's only one natural falls along the route from Pittsburgh (the confluence of the Allegheny and the Monongahela rivers) to Cairo (where it joins the Mississippi). It provides the plurality of the water to the Mississippi River, a little less than half of the total discharge. I don't know where you grew up, but the river is more comparable (in European terms) to the Rhine, Danube, Dnieper, Don, or Volga than something like the Thames or the Seine rivers.
Generally, low overpasses or turns that would be problematically tight.
E: Checking street view, for example: that Mink Rd overpass over I-70 is likely either too narrow or not rated for the weight.
https://www.google.com/maps/@39.9506421,-82.7300744,3a,75y,1...