.... and they call Lisp programmers "Smug Weenies"?

That said, there are two options if the OP _really_ wanted to use Pylons in Common Lisp.

One could attempt to run Pylons under cl-python[1], which is "a fairly complete implementation of Python written in Common Lisp". Cl-python is currently Allegro-only, and likely will not run Pylons without modification.

Alternately, there is Python-on-lisp, which is a FFI to an embedded python interpreter AFAICT. While it will likely be trivial to get Pylons running this way, the interface between the languages seems very low-level, and there does not seem to be any source translation from a sexp syntax to python.

I don't think either way is a good option honestly. If the OP wanted a python framework, they probably would have asked for one, and you could hold your head high rather than ducking ;).

Up-modded for good knowledge of Python-Lisp interfaces, surely something very cool.

That wasn't a smug weenie thing. It was funny. I was going to suggest web.py just for giggles.

What makes it funny exactly? To use an analogy (a poor one, like all), if this were a medical advice board, and someone had said 'I've got aids and i'm looking for a good retroviral" and the reply was "Chemo! <ducking>"..... I don't find that funny at all... just smug cancer weenies.